Apixaban for the Treatment of Japanese Subjects With Acute Venous Thromboembolism (AMPLIFY-J Study)

disease have resulted in a greater number of deaths attributed to PE in recent years in Japan.2 Whereas the early diagnosis and treatment of VTE can result in relatively good outcome, PE is a fatal disease characterized by a high rate of mortality; indeed, sudden death may be the presenting symptom of VTE.3 Early diagnosis and early treatment, including inhibition of DVT progression and prevention of PE recurrence are therefore very important in the treatment enous thromboembolism (VTE) is broadly divided into pulmonary embolism (PE) and deep vein thrombosis (DVT). PE and DVT have a common pathophysiology: PE is present in approximately 70% of DVT cases, and DVT is present in >30–70% of PE cases when assessed on computed tomography (CT) or perfusion.1 The increasing westernization of the Japanese lifestyle, the aging population, and a greater rate of diagnosis associated with awareness of the V